Rational design of an orthosteric regulator of hIAPP aggregation.
نویسندگان
چکیده
Developing compounds regulating amyloid toxic oligomer but not fibril formation should constitute an effective strategy for the treatment of diabetes. Based on the full understanding of the folding mechanism, we designed an orthosteric helix regulator that can promote hIAPP to assemble into large non-cytotoxic oligomers. As a result, the islet cells were protected.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 51 11 شماره
صفحات -
تاریخ انتشار 2015